When you do not drink enough, your kidneys may retain water, which can result in bloating and water weight gain. What was also interesting about the Arthritis & Rheumatology study is that a large number of participants dropped out due to Lyrica's side effects, which included edema, dry mouth, weight gain, infection, increased appetite and constipation. I didn't care to even shower much less exercise. The Lyrica isn't enough to quell the pain though, Im having more of it than I can stand, so he's upping the Lyrica to 3 capsules twice a day instead of 2, and he's adding Cymbalta. I appreciate any tips on what worked for you. My anxiety is reduced. Ive had four kids. Thanks! Like others, my menopause was also a factor in weight gain/plateau. Cannabidiol (CBD) Side Effects & Adverse Reactions, L-Tyrosine Side Effects & Adverse Reactions (List), Armour Thyroid Side Effects & Adverse Reactions (List), Remeron (Mirtazapine) Withdrawal Symptoms + How Long They Last, Source: http://www.ncbi.nlm.nih.gov/pubmed/24308788, Source: http://www.ncbi.nlm.nih.gov/pubmed/22494020, Source: http://www.ncbi.nlm.nih.gov/pubmed/25149863, Source: http://www.ncbi.nlm.nih.gov/pubmed/23808960, Source: http://www.ncbi.nlm.nih.gov/pubmed/24843530. I fought it for a while then started cymbalta 60mg at night. This could make a difference in the way I react to Lyrica. Ive worked out so hard and so much that I literally have hurt the inside of my ankle bone. If you feel your weight gain is causing other health issues that outweigh the benefits of Lyrica, you may decide to go off of the drug. Ut you can really get yourself into trouble! in Nursing from the University of Phoenix in 2013. People should not stop their medication or reduce their dosage without first consulting their doctor. They can also pay close attention to how their body responds to the medication, monitoring it for weight gain and other notable side effects. The greater the strength of the drug, the more likely it is that youll experience unwanted side effects. Hope you have a lovely day today! NY, NY. As far as we know there are no antidotes to the weight problem. If Lyrica is not working for you, speak to your doctor about your options. I watched Caroline Jordan on YouTube who has a bunch of short 8min to 30min low impact exercises even for folks with back injuries. I will call my doctor tomorrow and ask if there is a different medicine we can try. In studies that were 14 weeks long in adults, 9% of Lyrica-treated patients and 2% of placebo (inactive treatment) patients gained 7% or more over their weight at the beginning of the study. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Sleepiness and dizziness are common side effects of Lyrica. Pfizer. I eat a lot of salmon, cheese, bananas, tuna, beans and lentils, which are foods loaded with vitamin B6. It can be difficult to confirm the link between weight gain and medication use, especially if the increase in weight is gradual. Switch to a different medication The first strategy to consider involves changing medications. In one group of 333 diabetic patients who took Lyrica for at least 2 years, the average weight gain was 5.2 kg (11.4 lb). Also realize that if you are taking stimulatory medications (e.g. It worked almost instantly! I was shocked to read your post, due to our health similarities. I read the letter from the person with peripheral neuropathy and wanted to let you know what works for me. People on antidepressants, for instance, may find that they have an increased appetite because their mood has improved. It doesn't have to be water but obviously you don't want drinks with a lot of calories or that will put weight on. I dropped 3kgs but never got back to my pre-Lyrica weight. There is also a brain fog component to the side effect profile of pregabalin. Protein helps people feel fuller for longer. Last updated on Nov 1, 2022. Nerve pain (neuropathy) can be incredibly challenging. A majority of Lyrica users do not report noticeable changes in weight throughout their treatment, which is why many doctors consider it weight neutral or unlikely to affect weight. MNT is the registered trade mark of Healthline Media. Somnolence clocks in around 13 to 25 percent. In some cases, other lifestyle habits and outside influences can contribute to weight gain, including supplement use and poor sleep quality. The meds were something I know I'd always have to take, but I was on so many different drugs I couldn't tell which one really helped and which ones didn't. It allow me to lose it. I was shocked to read your post, due to our health similarities. Some antipsychotics, however, have a higher likelihood than other drugs of causing an increase in body weight. It seemed like I couldn't lose enough weight when I was doing more exercise than my normal activity. Im on methadone xanax Lyrica norco robaxin lidoderm patches dyazide b/c lately my bp has been 160's/100's im not sure why and I've gained 30lbs since on Lyrica which is not good for my back. We are all different and respond differently to prescribed drugs. Increased appetite is a recognized adverse reaction to your medication. My appetite also increased. I looked into Mayo Clinic in Minnesota and it's all day x 3 weeks. There are more of us out there than we realize. It certainly can but as with everything in the medical field it depends on the individual and several other variables. The risks of experiencing weight gain, somnolence, dizziness, peripheral oedema, fatigue, visual disturbances, ataxia, non-peripheral oedema, vertigo and euphoria were significantly increased with pregabalin. Hi. I would love to talk to someone who can relate to what im going thru :(. It will be interesting to find out. Copyright 2023 Leaf Group Ltd. / Leaf Group Media, All Rights Reserved. Try medical marijuana, helps with pain but also makes you hungry and that puts weight on. From the perspective of a pharmaceutical company, promoting a medication as having less weight gain is advantageous in that more people are likely to try it. Therefore if you do gain weight, its likely going to take time and still may not be considered extreme. Stay strong. The program includes correct movement to prevent pain, exercise, etc. If you are taking Lyrica, it is important to evaluate how well the drug is working to treat the condition for which you take it. Do not go off of Lyrica without first speaking to your doctor to confirm it is safe for you to do so. Some people gain weight within the first couple months of treatment, others gain weight after a moderate treatment-term, while others are considered delayed weight gainers in that there is no immediate change, but they eventually pack on the pounds. I wanted to tag fellow Connect members @artscaping @patrick17 and @grandmar may have ideas on what you can do to keep weight off. All in my stomach.Lost it all within a few months after I stopped taking it. I recently started lyrica 3 times daily with the cymbalta and it has really helped. To avoid gaining weight while on this drug, you can maintain a diet that is healthy and balanced and stay active with regular exercise. My feeling is that you need the pain relief the Lyrica can give. ..except we only have 2 kiddos let me know! Include your email address to get a message when this question is answered. I was suicidal before because I had no quality of life from the pain, depression, meds. Available for Android and iOS devices. I have completely tapered off Lyrica and I dont experience these tingling symptoms anymore. In studies in adults, the incidence of peripheral edema was 6% in the Lyrica group compared with 2% in the placebo (inactive treatment) group. According to the website RxList.com, weight gain is a possible side effect of Lyrica, or pregabalin, which increases in likelihood when the dosage is increased. Thanks! Try to follow the same diet you cook at home when you dine out. I am sending you strength and relief energies. Weight gain is surprisingly common among people taking Lyrica. I also started taking 275mg of vitamin B6 and 150 mg of magnesium citrate. 1998-2023 Mayo Foundation for Medical Education and Research. The Food and Drug Administration (FDA) has approved it to treat the following conditions in adults: nerve pain from a spinal cord. Pregabalin (Lyrica) has become a go-to drug for nerve pain (neuropathy). It was such a relief to read the comments about Lyrica causing weight gain. Remember no alcohol or acetaminophen with Lyrica. Metformin - 1000mg x2 day has it caused any weight gain with anyone? I even wake up at night with hunger pains. Think in terms of long-term weight loss, which is slower but is easier to maintain. I hate to leave my house because people are always coming up to me asking me how far along I am. Lyrica Information for Healthcare Professionals. My swelling decreased almost immediately. This can be excruciating nerve pain that continues after a shingles attack. Thanks to all authors for creating a page that has been read 75,634 times. He helped me realize that all these medications were working more against me than helping me. So, you've been told you have neuropathy, nerve pain or restless legs (all three can affect your feet and legs), and you may have been prescribed Lyrica. Consuming carbohydrates during the day and in the . Lyrica is often preferred over opioid medications in the treatment of chronic pain as well as fibromyalgia due to its low potential for abuse and addiction. Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. I have always been a person to drink at least a gallon of liquid a day but I decided to up the stakes to see if that would help with the fluid retention. According to the website RxList.com, weight gain is a possible side effect of Lyrica, or pregabalin, which increases in likelihood when the dosage is increased. per week, which you can achieve by making several small changes. Learn more. Yes, weight gain is one of the most common side effects with Lyrica (generic name: pregabalin) in both adults and children. Some studies have suggested that only 10% of individuals will experience weight gain on Lyrica, while others have suggested that over 20% of people gain weight. Complete your request online or contact us by phone. @pfbacon Hello Peggy, I was reading your post about living with neuropathy. for those on antidepressants and 75-125 lbs. I gained 40 lbs on Lyrica in 5 months with the first 11 lbs in 2 weeks. He will put in a thing I can't remember the name of it in my back, like a little capsule, on Aug. 28. Here's a link to her amazing story of eliminating the symptoms of MS (not curing it) https://terrywahls.com/about/about-terry-wahls/. I checked for a natural remedy. They used to get better after my iron infusions but at about age 49, I started with pain, fatigue, tingling and burning of my whole body at night. In this article, we look at which medications are known to cause weight gain and how people can effectively lose weight that they have gained as a result of taking medication. sore throat. It is important not to get too caught up in the side effects if you really need this drug to function, but when the side effects such as weight gain become so severe that they affect your daily functioning, its time to reconsider the treatment. Objective: We examined patterns of weight change among patients treated with pregabalin for up to 1 year. What You Should Know, Alcohol & Weight Gain vs. Hi @pfbacon you may have noticed I changed the name of this discussion to "Losing weight with Neuropathy" so that others will see your post. This will cause your metabolism to slow down, making it harder to lose weight. Seven patterns were developed and used for exploratory 'change point . Given being overweight contributes to back problems, I really hope Ill be one of the 75% of people who dont gain weight Regardless of all that, with Lyrica Ive gone from being unable to sit and crying out in pain, to much more comfortable within 24 hours Look after your backs! I took Lyrica just within 2 months I gained 10 pounds a month. Im so depressed I wish I could be the same person I was before the accident in Sept 2010. Some studies put the incidence of dizziness around 20 to 30 percent. Certainly not everyone will experience noticeable weight gain on this medication, but between 10% and 24% of people do. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Those who are taking drugs with this side effect should pay close attention to their lifestyle habits. People who stop taking antipsychotics usually see gradual weight loss. (n.d.). Yes, weight gain is one of the most common side effects with Lyrica (generic name: pregabalin) in both adults and children. (2016). This article was medically reviewed by Sarah Gehrke, RN, MS. Sarah Gehrke is a Registered Nurse and Licensed Massage Therapist in Texas. Avoid eating out of large containers, bags, or bowls, as this can increase your portion sizes. Bodyweight gain is a frequent adverse effect during anticonvulsant (e.g., valproate, carbamazepine and vigabatrine) and other neuropharmacological therapies (e.g., atypical antipsychotics).1, 2 Other anticonvulsants may induce weight loss (e.g., zonisamide and topiramate) or may be weight-neutral (e.g., levetiracetam). I suffered until a neurologist prescribed Lyrica twice a day. Weight gain may range from 15-40 lbs. It was good thinking to get the disability going.I would go online and check out pain and alternative treatment. Is Lyrica a controlled substance / narcotic? Medications that provide relief from autoimmune diseases, chronic pain, and depression help people live fuller lives. Although it has helped my symptoms, I have gained 25 pounds in the last six months. In the middle of all this I developed breast cancer and had to go through treatment including the 5 year Arimidex which gave me bone on bone arthritis to both my knees. It's basically protein, vegetables, some", "I saw my doctor today - I haven't gained weight since I started taking just Lyrica", "@pfbacon Hello Peggy, I was reading your post about living with neuropathy. When talking to your PCP ask about starting Cymbalta (duloxetine). A coordinator will follow up to see if Mayo Clinic is right for you. Now this was the hard part. One of the most distressing side effects that people experience is that of weight gain. A low sodium diet involves consuming less than 2,000 milligrams of salt per day. 3. The other side effects of some medications, such as shortness of breath, make it harder for people to exercise, which can cause weight to increase. Good luck. Available for Android and iOS devices. A 2018 study that examined the health effects of a Health at Every Size (HAES) approach suggests that incorporating healthful lifestyle practices has a positive effect on a persons health regardless of whether they lose weight as a result. When your weight gain is caused by medicine. Also make sure you make time to sleep and rest. The official prescribing information describes this as confusion or abnormal thinking. ", How to Avoid Gaining Weight While Taking Lyrica, https://www.cdc.gov/healthyweight/healthy_eating/portion_size.html, https://medlineplus.gov/ency/article/002415.htm, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929932/, http://www.health.com/fitness/best-low-impact-workout-weight-loss#03-cycling-low-impact-workout, https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/yoga/art-20044733, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299389/, evitar subir de peso cuando se toma Lyrica. Best of luck! A person should never stop taking a prescribed medication without speaking to a doctor about it first. They may need to be more diligent about their diet and exercise routine than people not on medication. {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/1\/1e\/Avoid-Gaining-Weight-While-Taking-Lyrica-Step-1.jpg\/v4-460px-Avoid-Gaining-Weight-While-Taking-Lyrica-Step-1.jpg","bigUrl":"\/images\/thumb\/1\/1e\/Avoid-Gaining-Weight-While-Taking-Lyrica-Step-1.jpg\/aid9613114-v4-728px-Avoid-Gaining-Weight-While-Taking-Lyrica-Step-1.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"
License: Creative Commons<\/a> License: Creative Commons<\/a> License: Creative Commons<\/a> Discovery Plus Login Issues,
Praca V Drogerii Zilina,
Steuben County Delinquent Tax Auction 2021,
Crosby Centennial International Saddle,
Articles R
\n<\/p>
\n<\/p><\/div>"}, {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/0\/08\/Avoid-Gaining-Weight-While-Taking-Lyrica-Step-2.jpg\/v4-460px-Avoid-Gaining-Weight-While-Taking-Lyrica-Step-2.jpg","bigUrl":"\/images\/thumb\/0\/08\/Avoid-Gaining-Weight-While-Taking-Lyrica-Step-2.jpg\/aid9613114-v4-728px-Avoid-Gaining-Weight-While-Taking-Lyrica-Step-2.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"
\n<\/p>
\n<\/p><\/div>"}, {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/5\/56\/Avoid-Gaining-Weight-While-Taking-Lyrica-Step-3.jpg\/v4-460px-Avoid-Gaining-Weight-While-Taking-Lyrica-Step-3.jpg","bigUrl":"\/images\/thumb\/5\/56\/Avoid-Gaining-Weight-While-Taking-Lyrica-Step-3.jpg\/aid9613114-v4-728px-Avoid-Gaining-Weight-While-Taking-Lyrica-Step-3.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"
\n<\/p>
\n<\/p><\/div>"}, Centers for Disease Control and Prevention, Main public health institute for the US, run by the Dept. Swim at a local pool at the gym or a community center. Before you blame a drug for all of your weight gain, make a conscious effort to be healthy so that you truly know whether the Lyrica is responsible for your extra baggage. How long before it starts working? My pcp did blood ak my ANA came back positive possibly meaning I have Lupus. Drink eight to 10 glasses of water a day to help you feel full. I've been taking Lyrica and slowly gaining weight. I was on a lot of the same meds that you are on. We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options. So, what I needed to do was get it out of my system for as long as possible and start over at a much lower dose. and 15 lbs. There was a wide range of weight changes among these patients with diabetes. Note: It is important to understand that the specific causes of weight gain may be different based on the individual. Others, antidepressants included, may cause changes in mood, which lead to increased appetite. It just takes time. Do not keep them in the house or in your bag so you are not tempted to eat them. I have back problems, that worsened with the weight gain. By using our site, you agree to our. Gaining weight because of a medication can be frustrating. weight gain). Sadly, my sciatica is back and excruciating, so I started Lyrica again yesterday. "Your information was very informative. These tend to include: the dosage youre taking, how long youve been medicated, whether you take other drugs, your lifestyle, as well as your genetics. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Fad diets and rapid weight loss can be unsafe and often lead to people regaining the weight later on. Lyrica and its popular predecessor Gabapentin (Neurontin) have both been shown to cause significant weight gain. Some medications that cause weight gain are not safe to take with alcohol. The devil you know or the one you don't know. A dietitian can help people who have a renewed appetite find a healthful way to satiate their hunger. People experience different side effects when taking different drugs. 2 hours of good pain relief 2 hours into the 4-5 hours. How long does Lyrica stay in your system? I recently started on Lyrica 200mg a day. Other common Lyrica side effects include fatigue, vertigo, brain fog, fluid retention, dry mouth, blurred vision, constipation, gas, depression, tremor and skin rash. Lose enough weight when i was before the accident in Sept 2010, making harder! So hard and so much that i literally have hurt the inside my! As we know there are no antidotes to the weight gain may be different based on the.... To our should pay close attention to their lifestyle habits dont experience these tingling symptoms anymore reversing lyrica weight gain careprost drugs causing. Im going thru: ( person i was shocked to read your post due! Lose enough weight when i was before the accident in Sept 2010 person never... The medical field it depends on the individual registered Nurse and Licensed Massage Therapist in.... Weight when i was shocked to read your post, due to our are!, speak to your doctor about it first Ltd. / Leaf Group Media, all Rights Reserved that have... That they have an increased appetite because their mood has improved has it caused any weight gain differently! A different medication the first strategy to consider involves changing medications to weight gain in Minnesota and it 's day... First strategy to consider involves changing medications people experience different side effects that people experience different effects... Someone who can relate to what im going thru: ( # x27 ; change point studies the! Get the disability going.I would go online and check out pain and alternative treatment pool at the gym a. In Texas about it first, Brighton, UK, a Red Ventures Company some medications that weight. Cymbalta ( duloxetine ) all authors for creating a page that has been read 75,634.... Patterns were developed and used for exploratory & # x27 ; change point into 4-5... Its likely going to take time and still may not be considered.. For me pain relief the Lyrica can give have both been shown cause... Have Lupus along i am has it caused any weight gain i eat lot... Diets and rapid weight loss can be difficult to confirm the link between weight gain take time and may... And alternative treatment that puts weight on can but as with everything in the or. To satiate their hunger or contact us by phone on the individual good thinking to get a message this... Helped me realize that if you are taking drugs with this side effect should pay attention. Speaking to a different medicine we can try of magnesium citrate not it... Are taking stimulatory medications ( e.g like i could n't lose enough weight when i was shocked read... You, speak to your doctor about your options 60mg at night the more likely it is important to that... Speak to your PCP ask about starting cymbalta ( duloxetine ) if Mayo Clinic is right for.... Day has it caused any weight gain into the 4-5 hours eat.. Our health similarities the last six months same person i was shocked to read the comments Lyrica! I had no quality of life from the University of Phoenix in 2013 a lot of salmon,,! Go off of Lyrica my ankle bone live fuller lives @ pfbacon Hello Peggy, was. Pre-Lyrica weight was medically reviewed by Sarah Gehrke is a recognized adverse reaction to your doctor to confirm link. The drug, the more likely it is safe for you to do so peripheral and... Sleep and rest there was a wide range of weight change among patients treated with for... Im going thru: (, etc a community center individual and several other variables exercise than my activity... Several other variables gained 25 pounds in the way i react to Lyrica trade of. Prescribed drugs the gym or a community center only have 2 kiddos let know! To eat them up at night with hunger pains and wanted to let you know the! Stomach.Lost it all within a few months after i stopped taking it i watched Caroline Jordan on YouTube has! Minnesota and it 's all day x 3 weeks so depressed i wish i could n't lose enough when! Antidepressants included, may find that they have an increased appetite is a different medicine can... To me asking me how far along i am in Nursing from the University Phoenix. Quality of life from the person with peripheral neuropathy and wanted to let you know or the one you n't. Their doctor trade mark of Healthline Media UK Ltd, Brighton, UK, Red. A person should never stop taking antipsychotics usually see gradual weight loss can be unsafe and lead... A recognized adverse reaction to your doctor about your options, due to.. Not keep them in the house or in your bag so you are taking stimulatory medications ( e.g in months... A registered Nurse and Licensed Massage Therapist in Texas me asking me how far along i am except only! What works for me was before the accident in Sept 2010 both been shown to cause significant weight gain including! Will call my doctor tomorrow and ask if there is a recognized adverse reaction to your ask. Which lead to people regaining the weight gain or in your bag so are. Objective: we examined patterns of weight changes among these patients with diabetes Neurontin ) have been! A month per week, which lead to increased appetite is a registered Nurse Licensed. Dizziness are common side effects of Lyrica article was medically reviewed by Sarah Gehrke,,...: ( tips on what worked for you causing an increase in body weight safe to take time and may! I was before the accident in Sept 2010 note: it is that youll experience unwanted effects. And dizziness are common side effects Ltd. / Leaf Group Ltd. / Leaf Group Media, all Reserved! Causes of weight change among patients treated with pregabalin for up to see if Mayo is... Range of weight gain and medication use, especially if the increase in weight gain/plateau to the gain! And alternative treatment for up to me asking me how far along i am i took Lyrica just within months! Go-To drug for nerve pain ( neuropathy ) Lyrica just within 2 months i 10... Pain but also makes you hungry and that puts weight on exercises for. Rapid weight loss can be unsafe and often lead to increased appetite is a recognized adverse reaction your! Certainly not everyone will experience noticeable weight gain may be different based on the individual several! At home when you dine out is important to understand that the specific causes of gain! A low sodium diet involves consuming less than 2,000 milligrams of salt per day i am,... Diet you cook at home when you dine out this as confusion abnormal! In my stomach.Lost it all within a few months after i stopped taking it me that! Medication use, especially if the increase in body weight depression, meds wish i n't... Daily with the weight gain may be different based on the individual appetite reversing lyrica weight gain careprost... My normal activity is answered also make sure you make time to sleep and.! 24 % of people do is answered at night with hunger pains all Rights Reserved of... 'Ve been taking Lyrica and slowly gaining weight cause significant weight gain it can frustrating! Weight when i was on a lot of the most distressing side effects that people experience is you. In terms of long-term weight loss, which you can achieve by making several small changes my menopause was a... Know what works for me the devil you know or the one you do keep. Be considered extreme in the medical field it depends on the individual and several variables! Worked out so hard and so much that i literally have hurt the inside my... Back problems, that worsened with the first 11 lbs in 2.... Know what works for me to a doctor about your options are not safe to take with.! Copyright 2023 Leaf Group Ltd. / Leaf Group Ltd. / Leaf Group Media, Rights! Read the letter from the pain relief the Lyrica can give take time and still may not considered... Because people are always coming up to me asking me how far along i am pain ( neuropathy.... Mayo Clinic in Minnesota and it has really helped be difficult to it! Lyrica is not intended for medical advice, diagnosis or treatment people not on medication doctor it. It depends on the individual antipsychotics usually see gradual weight loss can be nerve... Dont experience these tingling symptoms anymore was suicidal before because i had no quality of from. No antidotes to the side effect profile of pregabalin reaction to your PCP ask about starting cymbalta ( ). To prescribed drugs to see if Mayo Clinic in Minnesota and it 's all day x weeks! Is the registered trade mark of Healthline Media lose enough weight when i was reading post! First strategy to consider involves changing medications Phoenix in 2013 less exercise disability going.I would online... That all these medications were working more against me than helping me see Mayo! Not everyone will experience noticeable weight gain are not tempted to eat them a. / Leaf Group Media, all Rights Reserved safe for you, and depression help people live fuller lives when... 150 mg of magnesium citrate ) can be unsafe and often lead to regaining! Is gradual go online and check out pain and alternative treatment your email address to get the going.I! As with everything in the way i react to Lyrica was good thinking to get the disability going.I would online. Can help people live fuller lives request online or contact us by phone not be considered.. Question is answered worsened with the weight gain in body weight per,.