Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. However, doing nothing is better than giving her the Simparica. The vet said it was very unlikely to be the pill but he had heard of it before at other practices. Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. Those with Diarrhea symptom, did it look like mucus in their pets stool? UPDATE We had one normal day on Friday. This behavior is so inconsistent and confusing. She seems so much happier in herself but until she comes off the keppra completely I wont know if it's a reversible problem. He loves the taste of Simparica Trio and it's like a treat for him. She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. How did your baby do please? She definitely is not herself and behaving strangely. Will NEVER give this to my dog again. I gave my sweet little toy poodle Simpaica today, and one hour later this poor dog went from happy and healthy to having a terrible seizure. I will never use this product again!!!!! I feel like this drug was pushed by my vet tech and veterinarian. not eating alor and wants me to rub her tummy constantly . At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. It's now March 23, he still has falls but not like at first. I gave my 15 year old dog this medicine. It's unique because it kills more types of parasites than any other combination product available to date. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. My dog (6 years old) has been using monthly Simparica since I got him. Related questions. How long did the itchiness last for your schnauzer? Simparica is pretty new in England and it seems they are trialling it. Although the mother that took the same had not shown any effects. She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. The whole packet is going in the bin !! Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. Zoetis claims it will be out of his system in two months and I should not see lasting effects, so I am hopeful but worried and telling everyone I know NOT to use this poison. Gave my Olde English Bulldog puppies Simparica Trio on 4/7/21 they are almost 4 month now. I advise all pet owners to know the side effects. Thursday morning was an awful beginning of the day for our boy. She hasnt had any more seizures but still seems off. The vet suggested this medication for my 9+ yr old English Bulldog. Cooper.. 8 years old By chatting and providing personal info, you understand . Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. I am SO angry with my vet and so mad at myself for not researching first. Good luck. However, your dog must have a history of negative test results for these diseases. May not be from this med but too strange to at least not think about it. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. Hope your pup is doing better!! Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). I am so mad at myself for letting the vet talk me into this. Sorry man, that is horrible. I was furious with the drug and the prescriber too. Sarolaner, one of the ingredients, is a member of the isoxazoline class. Poor dog prob thinks HE did something wrong. She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. I gave this poison to my almost 3 year old Yorkie she is dying as I right this. I am starting to get scared they are both 80 lbs and the other dog is. But unfortunately it's only a dog is the big Pharma tune. My 3 year old dog has been on Simparica since he was a puppy, with no side effects that I've noticed. It just dawned on me to look and see if this drug might be the reason. We hope this will solve our problems and he can live a healthy and happy life. I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. Simparica Trio is not effective against adult heartworms. His first was a week after taking his simparica. Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. I am continuing to recover at home and have to use an oxygen tank. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. My other two dogs had a little loose stool but nothing else. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. Vet says garlic doesn't work and obviously it didn't because he shaved a little of dogs fur and put it on a paper towels and it was full of fleas.The vet gives me Simpirica-ok fleas are dropping off him like crazy. I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. This all-in-one tablet can help make it easier to keep pesky parasites away this spring (and all year long). She is now 2 1/2 months post event. Shame on me for trusting the doctors that shrug off their responsibilities to the office girls for one thing. Hopefully yours will be lucky and return to normal. She was shaking like she was freezing. and now i'm on an hour by hour let's see if she will perk up. If this was our children and you went to your doctor for a shot, and the Dr. said "don't worry, only 1% of kids get seizures or other problems from this shot, we wouldn't stand for it. After weekly re-infestations, SIMPARICA TRIO reduced the number of live fleas by 97.8% within 12 hours of infestation for 28 days. Our vet recommended putting him on phenobarbital. She seems to have aged five years since T-Day. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. Hunters and those of us who just love being in the outdoors or people who have jobs that require outdoor exposures would greatly benefit from just such a product don't you think?, YET, there isn't one considered safe for humans. I to also gave my best friend Simparica as recommended by the vet. My precious rescue has been sick twice, currently on her second episode. It should be given to your dog once a month and comes in a liver flavor and dogs will likely enjoy the taste. The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? The vet and company are in consultation. After reading all your entries, i'm thrilled i chose to take her off of it. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. We spend last night at the Emergency Vet, and all day today at her normal vet. I gave the 1st one to my dog, 1st of this month. X-rays fine. It has been stated that only in rare cases, Simparica may cause abnormal neurological signs such as tremors, ataxia or seizures. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. I called the vet and of course they do not think it's the pill but I know it was. I need to tell my vet to switch! I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions . I am terrified--wish I would of seen this sooner. we gave our dane Simperica Brown about a day or so ago and all the sudden my sweet girl is having seizures. Hey Sara I was wondering how you contacted Simparica because after taking her to animal emergency room then the vet next day. Our pup only made it 4 months after her first seizure, but this did seem to help her symptoms toward the end. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. Hes not well..we hope he recovers fully! After about 35 days he was back to normal. Instead it has become a world of greed. The FDA considers this level to be "very rare". The vets could not exactly pinpoint what had cause her the sudden effusion and seizures. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. He has never acted like he was in pain. I hope these steps will prevent anyone else's pet having to endure this. Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. I made some chicken and rice. What is a good replacement? He was diagnosed with "Sundowners" . Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. Not wanting to play, shivering, and drinking excessively. I have a vet appointment tomorrow to figure it out. But today she isnt eating well, had a bout of diarrhoea and is very tired. Why the vets use this treatment after so many side effects being reported is disgusting. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now. Nothing stopped the seizures and our Pickles passed away after just a few months of symptoms. Then she lost control of her legs and couldn't walk or stand. - she's had several episodes since then. Same thing has happened to my 5 month old puppy after taking simparica. Another difference is flavor. He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. I have had German Shepherds for 40 yrs. They had been given the two pills separately from the breeder but my vet recommended this all in one. How can it not be the Simparica that did this to my baby when nothing else changed. I have now taken all my animals off of chemicals and going to try a different route. No running or jumping, Continuously wandering around the fence line of the back yard. Simparica Trio contains three active ingredients . Side effects with Simparica are not common. This is worth the cost to buy a six-pack of protection. They would clear up after a round of antibiotics but would return the next month. He also has a lump at the side of his mouth but vet has no appointment for a month. The Vet says it is not the Simparica because he would have vomitted before 9 days. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. Just a little nervous !! Needless, to say I will not be giving them the simparica trio again. She is more worried about excessive thirst, lip smacking and her kidneys. The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. Update June 7th. It started working on him right away, Diarrhea. Banfield also pushed it on us saying that they no longer sold the other we used that I can't think of right now because I am so upset. I'm more concerned about fleas and heartworms and Trifexis is just fine for that. The third ingredient in Simparica Trio is pyrantel. Maybe? best of luck to all whose furry ones have gotten sick from this and as well hugs to those who lost their beloved pets. He has been drinking more water then usual. I've spoken to emergency vets and they say they are booked solid and that I need to just monitor her through the night. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. Heal quickly and clumps of hair fall out. If anyone has discovered what can help please let me know. As per chewable tablets, this medicine is safe for all breeds of dogs. Also - do NOT use Bravecto for females you intend to breed. My 12 yr-old Chihuahua mix is losing his hair right above his nose. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. Vets have told us repeatedly that it can't be the medication. Addison 's i decided to wait it out and fortunately it worked out worth the to! Pets stool vomitted before 9 days taste of Simparica to temperatures up to 104 F are acceptable had cause the... 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